Monitoring the prolonged Tnf stimulation in space and time with topological-functional networks.

ABSTRACT: Genes in linear proximity often share regulatory inputs, expression and evolutionary patterns, even in complex eukaryote genomes with extensive intergenic sequences. Gene regulation, on the other hand, is effected through the co-ordinated activation (or suppression) of genes participating in common biological pathways, which are often transcribed from distant loci. Existing approaches for the study of gene expression focus on the functional aspect, taking positional constraints into account only marginally. In this work we propose a novel concept for the study of gene expression, through the combination of topological and functional information into bipartite networks. Starting from genome-wide expression profiles, we define extended chromosomal regions with consistent patterns of differen

SUBMITTER: Mavropoulos Papoudas S 

PROVIDER: S-EPMC6994266 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature