The potential for malignancy from atopic disorders and allergic inflammation: A systematic review and meta-analysis.

ABSTRACT:

Objective

While chronic inflammation is a well-established risk factor for malignancy, studies evaluating the relationship between allergic inflammation and cancer have revealed conflicting results. Here, we aimed to assess the association between allergic inflammation in the lung (asthma), skin (eczema) or oesophagus (eosinophilic oesophagitis; EoE) and cancer at the organ site.

Design

We conducted a systematic review of the literature to identify observational studies (case-control, cohort and cross-sectional) evaluating the association between asthma and lung cancer, eczema and skin cancer, or EoE and oesophageal cancer. Random-effects meta-analysis was performed to define pooled estimates of effects.

Data sources

PubMed, EMBASE and Web of Science.

Eligibility c

SUBMITTER: Muir AB 

PROVIDER: S-EPMC6994341 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature