The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States.

ABSTRACT:

Background

Substantial progress has been made toward unraveling the genetic architecture of multiple sclerosis (MS) within populations of European ancestry, but few genetic studies have focused on Hispanic and African American populations within the United States.

Objective

We sought to test the relevance of common European MS risk variants outside of the major histocompatibility complex (n = 200) within these populations.

Methods

Genotype data were available on 2652 Hispanics (1298 with MS, 1354 controls) and 2435 African Americans (1298 with MS, 1137 controls). We conducted single variant, pathway, and cumulative genetic risk score analyses.

Results

We found less replication than statistical power suggested, particularly among African Americans. This c

SUBMITTER: Beecham AH 

PROVIDER: S-EPMC6994382 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature