Lactonization as a general route to β-C(sp³)-H functionalization.

ABSTRACT: Functionalization of the β-C-H bonds of aliphatic acids is emerging as a valuable synthetic disconnection that complements a wide range of conjugate addition reactions^1-5. Despite efforts for β-C-H functionalization in carbon-carbon and carbon-heteroatom bond-forming reactions, these have numerous crucial limitations, especially for industrial-scale applications, including lack of mono-selectivity, use of expensive oxidants and limited scope^6-13. Notably, the majority of these reactions are incompatible with free aliphatic acids without exogenous directing groups. Considering the challenge of developing C-H activation reactions, it is not surprising that achieving different transformations requires independent catalyst design and directing group optimizations in each

SUBMITTER: Zhuang Z 

PROVIDER: S-EPMC6994389 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature