Tumor regression during radiotherapy for non-small cell lung cancer patients using cone-beam computed tomography images.

ABSTRACT:

Purpose

Previous literature has reported contradicting results regarding the relationship between tumor volume changes during radiotherapy treatment for non-small cell lung cancer (NSCLC) patients and locoregional recurrence-free rate or overall survival. The aim of this study is to validate the results from a previous study by using a different volume extraction procedure and evaluating an external validation dataset.

Methods

For two datasets of 94 and 141 NSCLC patients, gross tumor volumes were determined manually to investigate the relationship between tumor volume regression and locoregional control using Kaplan-Meier curves. For both datasets, different subgroups of patients based on histology and chemotherapy regimens were also investigated. For the first dataset (n =

SUBMITTER: van Timmeren JE 

PROVIDER: S-EPMC6994551 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature