Absence of Functional Na_v1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes.

ABSTRACT:

Purpose

Several studies have indicated a potential role for SCN10A/Na_V1.8 in modulating cardiac electrophysiology and arrhythmia susceptibility. However, by which mechanism SCN10A/Na_V1.8 impacts on cardiac electrical function is still a matter of debate. To address this, we here investigated the functional relevance of Na_V1.8 in atrial and ventricular cardiomyocytes (CMs), focusing on the contribution of Na_V1.8 to the peak and late sodium current (I_Na) under normal conditions in different species.

Methods

The effects of the Na_V1.8 blocker A-803467 were investigated through patch-clamp analysis in freshly isolated rabbit left ventricular CMs, human left atrial CMs and human-induced pluripotent stem cell-derived

SUBMITTER: Casini S 

PROVIDER: S-EPMC6994555 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature