Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness.

ABSTRACT: Hydrogen sulfide (H₂S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H₂S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological roles of H₂S in the past decades. Manipulation of H₂S levels by inhibiting H₂S synthesis or administration of H₂S-releasing molecules revealed beneficial as well as harmful effects of H₂S. As a result, it is now established that H₂S levels are tightly controlled and too much or too little H₂S levels cause harm. Nonetheless, translation of sulfide-based therapy to clinical practice has been stymied due to the very low therapeutic index of sulfide and the incomplete understanding of en

SUBMITTER: Marutani E 

PROVIDER: S-EPMC6994583 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature