Building functional connectivity neuromarkers of behavioral self-regulation across children with and without Autism Spectrum Disorder.

ABSTRACT: Behavioral self-regulation develops rapidly during childhood and struggles in this area can have lifelong negative outcomes. Challenges with self-regulation are common to several neurodevelopmental conditions, including Autism Spectrum Disorder (ASD). Little is known about the neural expression of behavioral regulation in children with and without neurodevelopmental conditions. We examined whole-brain brain functional correlations (FC) and behavioral regulation through connectome predictive modelling (CPM). CPM is a data-driven protocol for developing predictive models of brain-behavior relationships and assessing their potential as 'neuromarkers' using cross-validation. The data stems from the ABIDE II and comprises 276 children with and without ASD (8-13 years). We identified networks wh

SUBMITTER: Rohr CS 

PROVIDER: S-EPMC6994646 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature