Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site.

ABSTRACT: Late-phase long-term potentiation (L-LTP) in hippocampus, thought to be the cellular basis of long-term memory, requires new protein synthesis. Neural activity enhances local protein synthesis in dendrites, which in turn mediates long-lasting synaptic plasticity. Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) is a locally synthesized protein crucial for this plasticity, as L-LTP is impaired when its local synthesis is eliminated. However, the distribution of Camk2a mRNA during L-LTP induction remains unclear. In this study, we investigated the dendritic targeting of Camk2a mRNA after high-frequency stimulation, which induces L-LTP in synapses of perforant path and granule cells in the dentate gyrus in vivoIn situ hybridization studies revealed that Camk2a mRNA was immediately but t

SUBMITTER: Nihonmatsu I 

PROVIDER: S-EPMC6994928 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature