Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations.

ABSTRACT:

Background

Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar molecular subtypes, we developed and validated a simple, mutually exclusive classification.

Methods

Mutational status of EGFR, KRAS, and TP53 was used to define seven mutually exclusive molecular subtypes. A development cohort of 283 cytology specimens of lung adenocarcinoma was used to evaluate the associations between the proposed classification and clinicopathologic variables including demographic characteristics, smoking history, fluorescence in situ hybridization and molecular results. For validation and prognostic assessment, 63 of the 283 cytology spec

SUBMITTER: Ruiz-Cordero R 

PROVIDER: S-EPMC6995064 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature