MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.

ABSTRACT:

Background

PARP inhibitors have been the most promising target drugs with widely proven benefits among ovarian cancer patients. Although platinum-response, HR-related genes, or HRD genomic scar detection are acceptably used in assessment of Olaparib response, there are still evident limitations in the present approaches. Therefore, we aim to investigate more accurate approaches to predict Olaparib sensitivity and effective synergistic treatment strategies.

Methods

We probed two databases (TCGA and Qilu Hospital) in order to quest novel miRNAs associated with platinum-sensitivity or HR-related genes. Cellular experiments in vitro or in vivo and PDX models were utilized to validate their role in tumor suppression and Olaparib sensitizing. Furthermore, HR gene mutation was anal

SUBMITTER: Sun C 

PROVIDER: S-EPMC6995078 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature