Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures.

ABSTRACT:

Background

The presence of tumor-associated stroma and tumor-infiltrated immune cells have been largely reported across glioblastomas. Tumor purity, defined as the proportion of tumor cells in the tumor, was associated with the genomic and clinicopathologic features of the tumor and may alter the interpretation of glioblastoma biology.

Methods

We use an integrative approach to infer tumor purity based on multi-omic data and comprehensively evaluate the impact of tumor purity on glioblastoma (GBM) prognosis, genomic profiling, and the immune microenvironment in the Cancer Genome Atlas Consortium (TCGA) cohort.

Results

We found that low tumor purity was significantly associated with reduced survival time. Additionally, we established a purity-relevant 5-gene signature t

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC6995093 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature