MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial.

ABSTRACT:

Background

Increased usage of genomic risk assessment assays suggests increased reliance on data provided by these assays to guide therapy decisions. The current study aimed to assess the change in treatment decision and physician confidence based on the 70-gene risk of recurrence signature (70-GS, MammaPrint) and the 80-gene molecular subtype signature (80-GS, BluePrint) in early stage breast cancer patients.

Methods

IMPACt, a prospective, case-only study, enrolled 452 patients between November 2015 and August 2017. The primary objective population included 358 patients with stage I-II, hormone receptor-positive, HER2-negative breast cancer. The recommended treatment plan and physician confidence were captured before and after receiving results for 70-GS and 80-GS. Treatmen

SUBMITTER: Soliman H 

PROVIDER: S-EPMC6995096 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature