Correlation between detergent activity and anti-herpes simplex virus-2 activity of commercially available vaginal gels.

ABSTRACT: OBJECTIVE:Herpes simplex virus-2 (HSV-2) infections are almost exclusively sexually transmitted. The presence of vaginal gels during sexual activity may have a significant positive or negative impact on viral transmission. Therefore we investigated three off-the-shelf vaginal lubricants and one pH restoring gel to evaluate their impact on HSV-2 replication. RESULTS:HeLa cells were infected with untreated virions and virions incubated with the particular gels. The accumulation of viral genomes was monitored by quantitative PCR (qPCR) method at 24 h post infection. Two of the tested gels had no significant effect on HSV-2 replication at the maximum applied concentration, while two had a strong inhibitory effect (~ 98% reduction of replication). The replication inhibitory effect was observed

SUBMITTER: Szollosi A 

PROVIDER: S-EPMC6995179 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature