BigTop: a three-dimensional virtual reality tool for GWAS visualization.

ABSTRACT: BACKGROUND:Genome-wide association studies (GWAS) are typically visualized using a two-dimensional Manhattan plot, displaying chromosomal location of SNPs along the x-axis and the negative log-10 of their p-value on the y-axis. This traditional plot provides a broad overview of the results, but offers little opportunity for interaction or expansion of specific regions, and is unable to show additional dimensions of the dataset. RESULTS:We created BigTop, a visualization framework in virtual reality (VR), designed to render a Manhattan plot in three dimensions, wrapping the graph around the user in a simulated cylindrical room. BigTop uses the z-axis to display minor allele frequency of each SNP, allowing for the identification of allelic variants of genes. BigTop also offers additional int

SUBMITTER: Westreich ST 

PROVIDER: S-EPMC6995189 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature