Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum.

ABSTRACT: BACKGROUND:An aberrant composition of the salivary microbiota has been found in individuals with type 2 diabetes, and in pregnant women salivary microbiota composition has been associated with preeclampsia and pre-term birth. Pregnant women, who develop gestational diabetes (GDM), have a high risk of developing type 2 diabetes after pregnancy. In the present study we assessed whether GDM is linked to variation in the oral microbial community by examining the diversity and composition of the salivary microbiota. METHOD:In this observational study the salivary microbiota of pregnant women with GDM (n = 50) and normal glucose regulation (n = 160) in third trimester and 9 months postpartum was assessed by 16S rRNA gene amplicon sequencing of the V1-V3 region. GDM was diagnosed in accordance wi

SUBMITTER: Crusell MKW 

PROVIDER: S-EPMC6995204 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature