Zmat2 in mammals: conservation and diversification among genes and Pseudogenes.

ABSTRACT:

Background

Recent advances in genetics and genomics present unique opportunities for enhancing our understanding of mammalian biology and evolution through detailed multi-species comparative analysis of gene organization and expression. Yet, of the more than 20,000 protein coding genes found in mammalian genomes, fewer than 10% have been examined in any detail. Here we elucidate the power of data available in publicly-accessible genomic and genetic resources by querying them to evaluate Zmat2, a minimally studied gene whose human ortholog has been implicated in spliceosome function and in keratinocyte differentiation.

Results

We find extensive conservation in coding regions and overall structure of Zmat2 in 18 mammals representing 13 orders and spanning ~ 165 million years o

SUBMITTER: Rotwein P 

PROVIDER: S-EPMC6995233 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature