Post-treatment of hyaluronan to decrease the apoptotic effects of carprofen in canine articular chondrocyte culture.

ABSTRACT: A major concern associated with the use of drugs is their adverse side effects. Specific examples of the drugs of concern include antibiotic agents and non-steroidal anti-inflammatory drugs. Despite the presence of a high degree of efficacy for specific conditions, these drugs may deteriorate the surrounding tissues that are exposed to them. Often, carprofen is used for joint inflammation; however, it may stimulate cartilage degradation which can then lead to osteoarthritis progression. In this study, hyaluronan was combined with carprofen treatment in three different applications (pre-treatment, co-treatment and post-treatment) on normal canine chondrocytes to determine whether Hyaluronan (HA) is capable of mitigating the degree of chondrotoxicity of carprofen. Our findings revealed that

SUBMITTER: Nganvongpanit K 

PROVIDER: S-EPMC6995269 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature