Assessment of Ki67 expression for breast cancer subtype classification and prognosis in the Nurses' Health Study.

ABSTRACT:

Purpose

Ki67 is a proliferation marker commonly assessed by immunohistochemistry in breast cancer, and it has been proposed as a clinical marker for subtype classification, prognosis, and prediction of therapeutic response. However, the clinical utility of Ki67 is limited by the lack of consensus on the optimal cut point for each application.

Methods

We assessed Ki67 by immunohistochemistry using Definiens digital image analysis (DIA) in 2653 cases of incident invasive breast cancer diagnosed in the Nurses' Health Study from 1976 to 2006. Ki67 was scored as continuous percentage of positive tumor cells, and dichotomized at various cut points. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox regression models for distant recurrence,

SUBMITTER: Healey MA 

PROVIDER: S-EPMC6995281 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature