A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications.

ABSTRACT: There is a growing awareness that complex 3-dimensional (3D) organs are not well represented by monolayers of a single cell type - the standard format for many drug screens. To address this deficiency, and with the goal of improving screens so that drugs with good efficacy and low toxicity can be identified, microphysiological systems (MPS) are being developed that better capture the complexity of in vivo physiology. We have previously described an organ-on-a-chip platform that incorporates perfused microvessels, such that survival of the surrounding tissue is entirely dependent on delivery of nutrients through the vessels. Here we describe an arrayed version of the platform that incorporates multiple vascularized micro-organs (VMOs) on a 96-well plate. Each VMO is independently-addressabl

SUBMITTER: Phan DTT 

PROVIDER: S-EPMC6995340 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature