Lobatamunsolides A-C, Norlignans from the Roots of Pueraria lobata and their Nitric Oxide Inhibitory Activities in Macrophages.

ABSTRACT: Phytochemical investigation of the methanol (MeOH) extract of Pueraria lobata roots, known as "kudzu", combined with liquid chromatography/mass spectrometry (LC/MS)-based analysis, resulted in the identification of four norlignans (1-4), including three new norlignans, lobatamunsolides A-C (1-3), and five known isoflavonoids (5-9). The structures of the new compounds were elucidated by a combination of spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high resolution (HR)-electrospray ionization mass spectrometry (ESIMS), and their absolute configurations were determined by chemical reaction and quantum chemical electronic circular dichroism (ECD) calculations. The isolated compounds (1-9) were eva

SUBMITTER: Jo MS 

PROVIDER: S-EPMC6995531 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature