Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics.

ABSTRACT: Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein-protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosi

SUBMITTER: Donate-Macian P 

PROVIDER: S-EPMC6995547 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature