Ontology highlight
ABSTRACT:
SUBMITTER: Endo T
PROVIDER: S-EPMC6995559 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Biomolecules 20191124 12
Retinoic acid (RA), a derivative of vitamin A, is critical for the production of oocytes and sperm in mammals. These gametes derive from primordial germ cells, which colonize the nascent gonad, and later undertake sexual differentiation to produce oocytes or sperm. During fetal development, germ cells in the ovary initiate meiosis in response to RA, whereas those in the testis do not yet initiate meiosis, as they are insulated from RA, and undergo cell cycle arrest. After birth, male germ cells ...[more]