Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.

ABSTRACT:

Purpose

The purpose of this study is to determine the effect of Cytoglobin (Cygb) deficiency on Crb1-related retinopathy. The Crb1 cell polarity complex is required for photoreceptor function and survival. Crb1-related retinopathies encompass a broad range of phenotypes which are not completely explained by the variability of Crb1 mutations. Genes thought to modify Crb1 function are therefore important targets of research. The biological function of Cygb involves oxygen delivery, scavenging of reactive oxygen species, and nitric oxide metabolism. However, the relationship of Cygb to diseases involving the Crb1 cell polarity complex is unknown.

Methods

Cygb knockout mice homozygous for the rd8 mutation (Cygb^-/-rd8/rd8) were screened for ocular abnormalities and ima

SUBMITTER: Kwon YS 

PROVIDER: S-EPMC6995765 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature