Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana.

ABSTRACT:

Background

A preliminary safety signal for neural-tube defects was previously reported in association with dolutegravir exposure from the time of conception, which has affected choices of antiretroviral treatment (ART) for human immunodeficiency virus (HIV)-infected women of reproductive potential. The signal can now be evaluated with data from follow-up of additional pregnancies.

Methods

We conducted birth-outcomes surveillance at hospitals throughout Botswana, expanding from 8 to 18 sites in 2018. Trained midwives performed surface examinations of all live-born and stillborn infants. Research assistants photographed abnormalities after maternal consent was obtained. The prevalence of neural-tube defects and major external structural defects according to maternal HIV infect

SUBMITTER: Zash R 

PROVIDER: S-EPMC6995896 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature