The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

ABSTRACT:

Background

Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining renal perfusion and controls glomerular arteriole tone and hemodynamics. It is hypothesized that ET-1 influences the progression of chronic kidney disease (CKD), and the objective of this review is to discuss the pathophysiology, and role of ET and endothelin receptor antagonists (ERAs) in CKD.

Summary

The use of ERAs in hypertensive nephropathy has the potential to decrease proteinuria, and in diabetic nep

SUBMITTER: Raina R 

PROVIDER: S-EPMC6995952 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature