Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure.

ABSTRACT:

Background

Metronidazole is the first-line treatment for bacterial vaginosis, but cure rates are suboptimal and recurrence rates high.

Objectives

To evaluate the impact of a standard course of oral metronidazole treatment (500 mg twice per day for 7 days) on the vaginal microbiota of Rwandan bacterial vaginosis patients using microscopy and 16S rRNA gene sequencing, and to evaluate correlates of treatment failure.

Study design

HIV-negative, nonpregnant women aged 18-45 years with bacterial vaginosis and/or Trichomonas vaginalis (N=68) were interviewed and sampled before and after metronidazole treatment. They were also screened, and treated if applicable, for other urogenital infections. The vaginal microbiota was assessed by Gram stain Nugent scoring, Illumina 16S rR

SUBMITTER: Verwijs MC 

PROVIDER: S-EPMC6995998 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature