Evidence of Endotypes in Pediatric Acute Hypoxemic Respiratory Failure Caused by Sepsis.

ABSTRACT: OBJECTIVES:Subclassification based on clinical or biologic commonalities (endotypes) is one approach to reduce heterogeneity in acute hypoxemic respiratory failure. In adults, biomarker-defined endotypes of respiratory failure have been described, with differential outcome profiles and response to therapy. To date, no studies have tested whether endotypes exist in pediatric acute hypoxemic respiratory failure, although messenger RNA expression-based endotypes have been described in pediatric sepsis. The aim of the present study was to test whether endotypes identified in pediatric sepsis are applicable to pediatric acute hypoxemic respiratory failure. DESIGN:Secondary analysis of a previously reported microarray-based study of pediatric sepsis. SETTING:Multiple PICUs in the United States.

SUBMITTER: Yehya N 

PROVIDER: S-EPMC6996087 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature