Longitudinal study of upper extremity reachable workspace in fascioscapulohumeral muscular dystrophy.

ABSTRACT: Facioscapulohumeral Dystrophy (FSHD) results in slowly progressive strength impairment, especially the upper extremities. Recent discoveries regarding pathophysiology have led to exciting novel therapeutic strategies. To further facilitate drug development, improved FSHD outcome measures that are functionally-relevant and sensitive to longitudinal change will be critical. Recently, a motion sensor (Kinect)-based upper extremity outcome called 'reachable workspace' that provides a quantitative reconstruction of an individual's reachability was developed. In this study, changes in reachable workspace were tracked upwards for five-years in 18 FSHD subjects. Results show -1.63 %/year decline in total reachable workspace (p = 0.144); with most notable decline in the above-the-shoulder level qua

SUBMITTER: Hatch MN 

PROVIDER: S-EPMC6996236 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature