Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.

ABSTRACT: To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique "sociophobia" acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y-maze. Assuming that social stimuli might be associated with characteristic thermo-responses, we exposed healthy men (N 

SUBMITTER: Seidel J 

PROVIDER: S-EPMC6996302 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature