Ontology highlight
ABSTRACT:
SUBMITTER: Tiburcy M
PROVIDER: S-EPMC6996344 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
FASEB bioAdvances 20191113 12
Satellite cells reside in defined niches and are activated upon skeletal muscle injury to facilitate regeneration. Mechanistic studies of skeletal muscle regeneration are hampered by the inability to faithfully simulate satellite cell biology in vitro. We sought to overcome this limitation by developing tissue engineered skeletal muscle (ESM) with (1) satellite cell niches and (2) the capacity to regenerate after injury. ESMs contained quiescent Pax7-positive satellite cells in morphologically d ...[more]