Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis.

ABSTRACT:

Background

Genetic risk factors can provide insight into susceptibility for acute pancreatitis (AP) and disease progression towards (infected) necrotizing pancreatitis and persistent organ failure. The aim of the study was to undertake a systematic review of the genetic evidence for AP.

Methods

Online databases (MEDLINE, Embase, BIOSIS, Web of Science, Cochrane Library) were searched to 8 February 2018. Studies that reported on genetic associations with AP susceptibility, severity and/or complications were eligible for inclusion. Meta-analyses were performed of variants that were reported by at least two data sources. Venice criteria and Bayesian false-discovery probability were applied to assess credibility.

Results

Ninety-six studies reporting on 181 variants in 79

SUBMITTER: van den Berg FF 

PROVIDER: S-EPMC6996643 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature