Prelingual Sensorineural Hearing Loss Caused by a Novel GJB2 Dominant Mutation in a Chinese Family.

ABSTRACT:

Background

GJB2 mutation is the most common cause of genetic deafness. Many pathogenic variations have already been identified, and thus, fewer and fewer novel pathogenic variations remain to be identified. Here, we describe a novel pathogenic variation associated with dominant hereditary deafness in a Chinese family.

Methods

In this study, we examined four generations of a Chinese family (M127) with hearing loss. Temporal CT scan, complete physical examination (including skin and hair), and audiological tests were performed. Targeted next-generation and Sanger sequencing were used to identify pathogenic mutations in affected individuals.

Results

All patients exhibited prelingual nonsyndromic sensorineural hearing loss, with severity ranging from moderate to se

SUBMITTER: Huang S 

PROVIDER: S-EPMC6996670 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature