Compromised steady-state germinal center activity with age in nonhuman primates.

ABSTRACT: Age-related reductions in vaccine-induced B cells in aging indicate that germinal centers (GCs), the anatomical site where the development of humoral responses takes place, may lose efficacy with age. We have investigated the baseline follicular and GC composition in nonhuman primates (NHPs) with respect to their age. There was a marked reduction in follicular area in old animals. We found significantly lower normalized numbers of follicular PD1^hi CD4 T (Tfh) and proliferating (Ki67^hi ) GC B cells with aging, a profile associated with significantly higher numbers of potential follicular suppressor FoxP3^hi Lag3^hi CD4 T cells. Furthermore, a positive correlation was found between Tfh and follicular CD8 T cells (fCD8) only in young animals. Despite

SUBMITTER: Shankwitz K 

PROVIDER: S-EPMC6996951 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature