Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.

ABSTRACT: Calcium binding proteins are expressed throughout the central and peripheral nervous system and disruption of their activity has major consequences in a wide array of cellular processes, including transmission of nociceptive signals that are processed at the level of the spinal cord. We previously reported that the calcium binding protein, hippocalcin-like 4 (Hpcal4), is heavily expressed in interneurons of the superficial dorsal horn, and that its expression is significantly downregulated in a TR4 mutant mouse model that exhibits major pain and itch deficits due to loss of a subpopulation of excitatory interneurons. That finding suggested that Hpcal4 may be a contributor to the behavioral phenotype of the TR4 mutant mouse. To address this question, here we investigated the behavioral cons

SUBMITTER: Alvaro CG 

PROVIDER: S-EPMC6996964 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature