Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses.

ABSTRACT: We performed a transcriptome-wide meta-analysis and gene co-expression network analysis to identify genes and gene networks dysregulated in the peripheral blood of bipolar disorder (BD) cases relative to unaffected comparison subjects, and determined the specificity of the transcriptomic signatures of BD and schizophrenia (SZ). Nineteen genes and 4 gene modules were significantly differentially expressed in BD cases. Thirteen gene modules were shown to be differentially expressed in a combined case-group of BD and SZ subjects called "major psychosis", including genes biologically linked to apoptosis, reactive oxygen, chromatin remodeling, and immune signaling. No modules were differentially expressed between BD and SZ cases. Machine-learning classifiers trained to separate diagnostic class

SUBMITTER: Hess JL 

PROVIDER: S-EPMC6997041 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature