Maternal MTNR1B genotype, maternal gestational weight gain, and childhood obesity.

ABSTRACT:

Background

Maternal metabolic abnormalities have been related to offspring obesity especially during childhood.

Objectives

We analyzed whether the gestational diabetes mellitus (GDM)-associated melatonin receptor 1B (MTNR1B) genotype of mothers modified the relation between maternal gestational weight gain and childhood obesity.

Methods

A total of 1114 Chinese mother-child pairs (mothers with or without prior GDM) were included. Mothers' MTNR1B rs10830962 genotype and gestational weight gain were assessed. Indicators of childhood obesity included BMI-for-age z-score, weight-for-age z-score, waist circumference, and body fat. Childhood overweight and obesity were also analyzed.

Results

We found that the maternal MTNR1B genotype significantly interacted with gest

SUBMITTER: Liang Z 

PROVIDER: S-EPMC6997086 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature