The prognostic value of lncRNA SNHG4 and its potential mechanism in liver cancer.

ABSTRACT: Emerging evidence shows that non-coding RNA functions as new gene regulators and prognostic markers in several cancers, including liver cancer. Here, we focused on the small nucleolar RNA host gene 4 (SNHG4) in liver cancer prognosis based on The Cancer Genome Atlas (TCGA) data. The expression data and clinical information were downloaded from TCGA. Chi-square tests evaluated the correlation between SNHG4 expression and clinical parameters. Differences in survival between high and low expression groups (optic cutoff value determined by ROC) from Cox regression analysis were compared, and P-value was calculated by a log-rank test. Kaplan-Meier curves were compared with the log-rank test. GSEA and ceRNA network were conducted to explore the potential mechanism. Data mining of lncRNA expressi

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC6997108 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature