Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.

ABSTRACT: The study of hereditary cancer, which accounts for ~10% of cancer cases worldwide is an important subfield of oncology. Our understanding of hereditary cancers has greatly advanced with recent advances in sequencing technology, but as with any genetic trait, gene frequencies of cancer-associated mutations vary across populations, and most studies that have located hereditary cancer genes have been conducted on European or Asian populations. There is an urgent need to trace hereditary cancer genes across the Arab world. Hereditary disease is particularly prevalent among members of consanguineous populations, and consanguineous marriages are particularly common in the Arab world. There are also cultural and educational idiosyncrasies that differentiate Arab populations from other more thorou

SUBMITTER: AlHarthi FS 

PROVIDER: S-EPMC6997177 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature