Bioreactor With Electrically Deformable Curved Membranes for Mechanical Stimulation of Cell Cultures.

ABSTRACT: Physiologically relevant in vitro models of stretchable biological tissues, such as muscle, lung, cardiac and gastro-intestinal tissues, should mimic the mechanical cues which cells are exposed to in their dynamic microenvironment in vivo. In particular, in order to mimic the mechanical stimulation of tissues in a physiologically relevant manner, cell stretching is often desirable on surfaces with dynamically controllable curvature. Here, we present a device that can deform cell culture membranes without the current need for external pneumatic/fluidic or electrical motors, which typically make the systems bulky and difficult to operate. We describe a modular device that uses elastomeric membranes, which can intrinsically be deformed by electrical means, producing a dynamically tuneable cur

SUBMITTER: Costa J 

PROVIDER: S-EPMC6997204 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature