Deficits in response inhibition on varied levels of demand load in anorexia nervosa: an event-related potentials study.

ABSTRACT:

Purpose

The aim of the present study was to investigate the executive function of inhibitory control in anorexia nervosa (AN), which is considered as an underlying pathophysiology of restricting eating.

Methods

In this work, we examined the function of response inhibition in 27 unmedicated AN patients and 30 healthy controls (HC) using stop-signal tasks with different demand loads. Two event-related potentials (ERP) during the stop-signal tasks, N2 and P300, were compared between the AN and HC groups.

Results

We found attenuated P300 amplitudes and delayed N2 latencies in AN patients across all three demand loads compared to HCs. We also found significant interaction between group and level of demand load. N2 latencies were prolonged when the inhibitory demand was low

SUBMITTER: Yue L 

PROVIDER: S-EPMC6997249 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature