Effect of High Calorie Diet on Intestinal Flora in LPS-Induced Pneumonia Rats.

ABSTRACT: Intestinal flora plays an important role in inflammatory response to systemic or local organs of its host. High calorie diet has been shown to aggravate the condition of pneumonia and delay recovery, especially in children. However, the underlying mechanisms remain unclear. This study placed SPF rats in a conventional environment, high calorie diet or LPS atomization was performed respectively or combined. Analysis of high-throughput sequencing of intestinal content combined with animal weight, organ index, serum inflammatory factors indicators and bioinformatics found that after pulmonary infection combined with a high-calorie diet, rats showed significant changes such as weight loss and increased lung weight index, and their lung and intestinal tissues showed more obvious inflammatory ch

SUBMITTER: Bai C 

PROVIDER: S-EPMC6997398 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature