Development of an Immune-Related Prognostic Signature in Breast Cancer.

ABSTRACT:

Background

Although increased early detection, diagnosis and treatment have improved the outcome of breast cancer patients, prognosis estimation still poses challenges due to the disease heterogeneity. Accumulating data indicated an evident correlation between tumor immune microenvironment and clinical outcomes.

Objective

To construct an immune-related signature that can estimate disease prognosis and patient survival in breast cancer.

Methods

Gene expression profiles and clinical data of breast cancer patients were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, which were further divided into a training set (n = 499), a testing set (n = 234) and a Meta-validation set (n = 519). In the training set, immune-related genes were

SUBMITTER: Xie P 

PROVIDER: S-EPMC6997532 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature