Genomic Diversity Evaluation of Populus trichocarpa Germplasm for Rare Variant Genetic Association Studies.

ABSTRACT: Genome-wide association studies are powerful tools to elucidate the genome-to-phenome relationship. In order to explain most of the observed heritability of a phenotypic trait, a sufficient number of individuals and a large set of genetic variants must be examined. The development of high-throughput technologies and cost-efficient resequencing of complete genomes have enabled the genome-wide identification of genetic variation at large scale. As such, almost all existing genetic variation becomes available, and it is now possible to identify rare genetic variants in a population sample. Rare genetic variants that were usually filtered out in most genetic association studies are the most numerous genetic variations across genomes and hold great potential to explain a significant part of the

SUBMITTER: Piot A 

PROVIDER: S-EPMC6997551 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature