Functional and structural connectivity substrates of cognitive performance in relapsing remitting multiple sclerosis with mild disability.

ABSTRACT: Multiple Sclerosis (MS) is the most common chronic inflammatory and neurodegenerative disease of the central nervous system (CNS), which can lead to severe cognitive impairment over time. Magnetic resonance imaging (MRI) is currently the best available biomarker to track MS pathophysiology in vivo and examine the link to clinical disability. However, conventional MRI metrics have limited sensitivity and specificity to detect direct associations between symptoms and their underlying CNS substrates. In this study, we aimed to investigate structural and resting state functional connectomes and subnetworks associated with neuropsychological (NP) performance using a graph theoretical approach. A comprehensive NP test battery was administered in a sample of patients with relapsing remitting MS (

SUBMITTER: Has Silemek AC 

PROVIDER: S-EPMC6997626 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature