Reorganization of rich-clubs in functional brain networks during propofol-induced unconsciousness and natural sleep.

ABSTRACT:

Background

General anesthesia (GA) provides an invaluable experimental tool to understand the essential neural mechanisms underlying consciousness. Previous neuroimaging studies have shown the functional integration and segregation of brain functional networks during anesthetic-induced alteration of consciousness. However, the organization pattern of hubs in functional brain networks remains unclear. Moreover, comparisons with the well-characterized physiological unconsciousness can help us understand the neural mechanisms of anesthetic-induced unconsciousness.

Methods

Resting-state functional magnetic resonance imaging was performed during wakefulness, mild propofol-induced sedation (m-PIS), and deep PIS (d-PIS) with clinical unconsciousness on 8 healthy volunteers and wake

SUBMITTER: Wang S 

PROVIDER: S-EPMC6997627 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature