Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators.

ABSTRACT: The incidence of Alzheimer's disease (AD) has risen exponentially worldwide over the past decade. A growing body of research indicates that AD is linked to diabetes mellitus (DM) and suggests that impaired insulin signaling acts as a crucial risk factor in determining the progression of this devastating disease. Many studies suggest people with diabetes, especially type 2 diabetes, are at higher risk of eventually developing Alzheimer's dementia or other dementias. Despite nationwide efforts to increase awareness, the prevalence of Diabetes Mellitus (DM) has risen significantly in the Middle East and North African (MENA) region which might be due to rapid urbanization, lifestyle changes, lack of physical activity and rise in obesity. Growing body of evidence indicates that DM and AD are li

SUBMITTER: Jayaraj RL 

PROVIDER: S-EPMC6997863 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature