Thyroid Hormone Receptor β Inhibits Self-Renewal Capacity of Breast Cancer Stem Cells.

ABSTRACT: Background: A subpopulation of cancer stem cells (CSCs) with capacity for self-renewal is believed to drive initiation, progression, and relapse of breast tumors. Methods: Since the thyroid hormone receptor β (TRβ) appears to suppress breast tumor growth and metastasis, we have analyzed the possibility that TRβ could affect the CSC population using MCF-7 cells grown under adherent conditions or as mammospheres, as well as inoculation into immunodeficient mice. Results: Treatment of TRβ-expressing MCF-7 cells (MCF7-TRβ cells) with the thyroid hormone triiodothyronine (T3) decreased significantly CD44⁺/CD24^- and ALDH⁺ cell subpopulations, the efficiency of mammosphere formation, the self-renewal capacity of CSCs in li

SUBMITTER: Lopez-Mateo I 

PROVIDER: S-EPMC6998057 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature