Characteristics and outcomes in patients with atrial fibrillation receiving direct oral anticoagulants in off-label doses.

ABSTRACT:

Background

We evaluated adherence to dosing criteria for patients with atrial fibrillation (AF) taking dabigatran or rivaroxaban and the impact of off-label dosing on thromboembolic and bleeding risk.

Methods

We used data for a retrospective cohort from a large U.S. health plan for Medicare beneficiaries age > =65 years with AF who initiated dabigatran or rivaroxaban during 2010-2016. Stroke and major bleeding were quantified in patients who were eligible for low dose but received standard dose, and in patients who were eligible for standard dose but received low dose.

Results

We identified 8035 and 19,712 patients who initiated dabigatran or rivaroxaban, respectively. Overall, 1401 (17.4%) and 7820 (39.7%) patients who received dabigatran and rivaroxaban met criteria

SUBMITTER: Briasoulis A 

PROVIDER: S-EPMC6998084 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature