Fecal microbiota transplantation to maintain remission in Crohn's disease: a pilot randomized controlled study.

ABSTRACT:

Background

The role of the gut microbiota in Crohn's disease (CD) is established and fecal microbiota transplantation (FMT) is an attractive therapeutic strategy. No randomized controlled clinical trial results are available. We performed a randomized, single-blind, sham-controlled pilot trial of FMT in adults with colonic or ileo-colonic CD.

Method

Patients enrolled while in flare received oral corticosteroid. Once in clinical remission, patients were randomized to receive either FMT or sham transplantation during a colonoscopy. Corticosteroids were tapered and a second colonoscopy was performed at week 6. The primary endpoint was the implantation of the donor microbiota at week 6 (Sorensen index > 0.6).

Results

Eight patients received FMT and nine sham transplantati

SUBMITTER: Sokol H 

PROVIDER: S-EPMC6998149 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature